Product Composition

This is a maintenance therapy combination medicine presented as a dry powder pre-filled into specialized capsules for inhalation. Each single-dose capsule contains a precise blend of:

• Active Ingredients: Salmeterol (as Xinafoate) and Fluticasone Propionate IP.

• Indicative Dose: The product name ‘Mistovate-S 500’ and the context strongly imply a combined dose of 500 mcg, likely split as 50 mcg of Salmeterol and 450 mcg of Fluticasone Propionate per dose. Crucially, refer to your exact prescription for the correct dose.

Summary

Mistovate®-S 500 is a maintenance treatment designed for the long-term control of severe persistent symptoms of asthma and chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It pairs a long-acting bronchodilator (Salmeterol), which relaxes muscles in the airways to keep them open, with a powerful, high-dose anti-inflammatory corticosteroid (Fluticasone Propionate), which reduces swelling and inflammation. This synergistic combination provides stable, target 24-hour symptom control when used daily.

Pros and Cons

Pros:

• Powerful Maintenance Control: Highly effective for managing severe persistent symptoms of asthma and COPD, significantly reducing the frequency and severity of severe flare-ups.

• Dual Synergistic Action: Addresses both the muscle constriction (bronchospasm) and the underlying inflammation that cause severe symptoms.

• Once or Twice Daily Dose: Offers the option for less frequent dosing depending on the severity and physician instructions, which can improve compliance.

Cons:

• Not a Rescue Inhaler: Must not be used for sudden attacks or severe flare-ups. A fast-acting reliever inhaler (like salbutamol) must still be carried at all times.

• Prescription Required: Available only with a physician’s prescription and under strict medical supervision.

• Potential for Side Effects: Common side effects can include a sore throat, headaches, muscle cramps, and a very high risk of serious oral thrush infections (mouth infections) with prolonged, daily use. Rare but serious risks also exist, such as high blood pressure or increased cardiac effects.

• Use with Caution: Requires careful use in patients with thyroid or kidney conditions.

• Photosensitivity: Doxycycline can cause increased sensitivity to sunlight.

How to Use

• Consult Your Doctor: Strictly adhere to the exact dose, timing, and device-use instructions your physician has prescribed. It must only be used with the dedicated inhalation device.

• ** timing:** Take the medication at the same time(s) each day to maintain steady drug levels in your blood. It can typically be taken with or without food, but follow your doctor’s instructions.

• Capsule handling: Identify the recommended method (typically either placing the opened capsule on a tissue/pillow or, for more intense relief, adding it to a steam inhalation setup). Consult a health professional or the detailed leaflet for the exact application instructions and safety precautions for your specific age and condition.

• Prevention of Side Effects: Immediately after each and every once-daily dose, rinse your mouth out thoroughly with water (do not swallow the water). This is a crucial step to prevent common infections in the mouth and throat.

• Use with Caution: Requires careful use in patients with thyroid or kidney conditions.

• Photosensitivity: Doxycycline can cause increased sensitivity to sunlight.

Product Description

Mistovate®-S 500 is a high-dose, prescription-only maintenance medication supplied in a carton containing a bottle of 30 specialized capsules and a dedicated inhalation device. Each single-use capsule contains a precise powder blend of the long-acting bronchodilator Salmeterol and the powerful anti-inflammatory corticosteroid Fluticasone Propionate IP. It is indicated for the long-term, comprehensive control of persistent wheezing, shortness of breath, coughing, and chest tightness in patients with severe persistent asthma and COPD, by targeting both severe airway constriction and underlying persistent inflammation. The product is marketed by Healthgate.