Product Description

This product, marketed by Healthgate, is a fixed-dose combination medication containing Domperidone and Naproxen Sodium, branded as Nadom 500. The medication is presented in a white cardboard box with a curved light blue band and colored ring accents. The packaging indicates that it contains 10 strips of 15 tablets each (a total of 150 tablets). The strip in the image is a standard aluminum blister pack holding fifteen oval-shaped, presumably white or light-colored, film-coated tablets.

Product Composition

This medication contains two active ingredients:

• Naproxen Sodium (500 mg): A non-steroidal anti-inflammatory drug (NSAID) that acts as a potent pain reliever and reduces inflammation and fever.

• Domperidone (10 mg): An antiemetic and prokinetic agent. It helps to prevent nausea and vomiting, and speeds up the movement of food through the stomach.

The tablet is film-coated, as mentioned on the strip.

Summary

Nadom 500 is a prescription medication primarily used to prevent and treat migraine headaches. It combines the powerful pain-relieving action of Naproxen with the anti-nausea/anti-vomiting properties of Domperidone. This dual action is particularly effective for migraines, which are often accompanied by severe nausea and stomach stagnation. By taking them together, the Naproxen works more effectively to relieve the pain, while the Domperidone manages the associated gastric symptoms and improves drug absorption.

Pros and Cons

Pros

• Dual-Action Relief: Combines a strong pain reliever with an anti-nausea agent, addressing multiple symptoms of a migraine in one tablet.

• Improved Efficacy for Migraines: Domperidone helps to prevent “gastric stasis” (stomach slowing down), which allows the Naproxen to be absorbed more quickly and work better to stop the pain.

• Convenient Formulation: Provides a fixed dose in a single tablet, simplifying the treatment regimen.

Cons

• Potential for Common Side Effects: Common side effects can include stomach upset, nausea, headache, dizziness, or drowsiness.

• Gastrointestinal and Cardiovascular Risks (Naproxen): NSAIDs like Naproxen can increase the risk of serious stomach bleeding or ulcers, especially with long-term use. They can also slightly increase the risk of heart attack or stroke.

• Domperidone-Related Cardiovascular Risks: Rarely, Domperidone can cause serious heart rhythm problems (QT prolongation). This risk is generally higher at high doses or in people with pre-existing heart conditions.

• Interacts with many medicines: Can have serious interactions with blood thinners, other NSAIDs, and certain antibiotics or antifungals.

How to Use

This medication is strictly prescription-only and must be used exactly as directed by your healthcare professional. Below is a general guide.

1. Dose and Timing for Acute Migraine: For an acute migraine attack, typically one tablet should be taken as soon as possible after the onset of the migraine headache. Do not exceed the prescribed dose.

2. Take with Water: Swallow the tablet whole with a full glass of water.

3. Maximum Daily Dosage: The dosage for preventing or treating multiple migraines will be determined by your doctor. It is critical not to exceed the maximum daily dose prescribed.

4. Avoid Alcohol: Consuming alcohol while taking this medication can increase the risk of stomach bleeding.

5. Inform Your Doctor: Tell your doctor about any pre-existing medical conditions, especially heart, liver, or kidney disease, stomach ulcers, asthma, or any bleeding disorders. Inform them of all other medications you are taking.

6. Seek Medical Help Immediately: Contact your doctor at once if you experience signs of stomach bleeding (black/bloody stools, bloody vomit), severe stomach pain, unusual fatigue, fainting, irregular heartbeat, sudden vision changes, or signs of a stroke (slurred speech, weakness on one side).